Welcome to The Age-Related Eye Disease Study 2 (AREDS2) was a multi-center, randomized trial designed to assess the effects of oral. The Age-Related Eye Disease Study 2 (AREDS2) Research Group* . AREDS2 was designed to test whether adding lutein + zeaxanthin, DHA. Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 (AREDS2).

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Chemistry and metabolism of lipids in the vertebrate retina.

Eyes that had undergone cataract surgery at least 3 months prior to enrollment were eligible; eyes that had undergone other intraocular surgeries were not included.

Get free access to newly published articles. All analyses were conducted following the intention-to-treat principle. Of the remaining participants, The study was conducted in a population that was, on average, ten years older than in the original AREDS study, and at a higher risk of disease progression. Blood levels of vitamin C, carotenoids and retinol are inversely associated areda2 cataract in a North Indian Population.

Certified photographers obtain stereoscopic fundus photographs of the macula and optic nerve and masked graders use a standard protocol to grade the photographs. The median age is 74 years. Comparison with placebo in the primary analyses demonstrated no statistically significant reduction in progression to advanced AMD hazard ratio [HR], 0. Studdy drusen in one eye, less than large drusen fellow eye c.

Prog Retin Eye Res. Thereafter, study procedures included confirmation of eligibility by the Reading Center prior to randomization.

Study concept and design: Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Incorrect Information in Tables.

Population characteristics at baseline were as follows: Lipids, Learning, and the Brain: Neovascular age-related macular degeneration and its relationship to antioxidant intake. Xanthophylls and alpha-tocopherol decrease UVB-induced lipid peroxidation and stress signaling in human lens epithelial cells. All enrolled participants will be followed until November allowing for a median of 5 years of follow-up or until the Data and Safety Monitoring Committee DSMC has recommended earlier trial termination.


Participants were able to select more than 1 racial category. It did not have a lower rate of side effects and there was a statistically non-significant trend to reduced efficacy, compared to the original, higher dose. Without more effective ways of slowing progression, the number of persons with advanced AMD is expected to double over the next 20 years, resulting in increasing socioeconomic burden. Ancillary studies are also conducted to evaluate the role of the AREDS2 nutritional supplements on cardiovascular disease and cognitive function.

The primary purpose of the study is a comparison of the aresd2 active treatment arms to placebo on progression to advanced AMD based on reading center grading of color stereoscopic fundus photographs in study eyes. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: Lutein and zeaxanthin atudy the only carotenoids detected in the human lens.

AREDS2 Results Released

The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: Participants who were current smokers or former smokers who had stopped smoking within the year prior to enrollment were randomly assigned to one of the two arms without beta-carotene Formulations 2 or 4.

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Dose-ranging study of lutein supplementation in persons aged 60 years or older [published correction appears in Invest Ophthalmol Vis Sci. J Natl Cancer Inst. Elevated retinal zeaxanthin and prevention of light-induced photoreceptor cell death in quail.

Dietary carotenoids, vitamins A, C, and E, advanced age-related macular degeneration. Eye Diseases Prevalence Research Group. This reflects the change in clinical practice over time. Posterior Subcapsular Opacities on Photographs. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. AREDS2 is powered to assess a similar further reduction in the treatment arms compared with the control arm, which would be considered clinically important.


At baseline and at each annual study visit, participants received a comprehensive eye exam including best-corrected visual acuity obtained with the electronic version of the ETDRS visual acuity charts. Effects of alpha-tocopherol and beta-carotene supplements on cancer incidence in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study.

Cataract surgery and the primary care practitioner. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: Fish oil and postoperative atrial fibrillation: Beta carotene had been used in this formulation because lutein and zeaxanthin were not commercially available at the start of AREDS. Oral zinc in macular degeneration. Masked graders at a central reading center used a standard protocol to assess the photographs.

Institutional review boards approved the AREDS2 research protocol, and all participants provided written informed consent. The tolerable upper level of daily zinc intake is 40 mg. People with early disease or late disease in both eyes were not included in the study. Follow-up study visits were scheduled annually; follow-up also included telephone contact 3 months after randomization and subsequent telephone contacts at 6 months between study visits.

AREDS2 Results Released | Macular Disease Foundation Australia

A number of ancillary studies of imaging including fundus autofluorescence FAFwide-angle fundus photographs, and spectral domain optical coherence tomography OCT are being collected from a large number of AREDS2 participants. The impact of fish and shellfish consumption on age-related macular degeneration. We also have not tested for equivalency between low-dose zinc and high-dose zinc and between no beta carotene and beta carotene. Observational data from AREDS, other epidemiologic arers2 and animal studies, provide a rationale for examining the potential impact of other nutrients on the treatment of AMD.