Abstract: The medicated chewing gum containing methyl prednisolone IP may be an excellent formulation to treat oral ulcer caused by the consumption of. An attempt has been made to formulate new chewing gum device for metaclopramide in the form of tablet. The new drug delivery system was obtained , at room. Formulation and evaluation of medicated chewing gum as antiplaque and antibacterial agent. S Vasudha Lakshmi1, Hemant KS Yadav1*, KP Mahesh2, Swati.
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Formulation And Evaluation Of Medicated Chewing Gum Of Metaclopramide |
To carry out in vivo study on humans double-blind, crossover clinical trial was conducted on 18 adult volunteers from Department of Oral Medicine and Radiology, JSS Dental College, Mysore. Journal of Current Pharma Research ; 4 4: Hence, Metaclopramide chewing gum can be considered as a better formulation for the buccal drug delivery system, in which drug is absorbed buccally and reaches the systemic circulation via jugular vein.
Simple diffusion into the medium causes the release of only a small percentage of the drug contained in the medicated chewing gum, while the delivery of the major part of the dose occurs during mastication. Downloads Download data is not yet available. Volume 7, Issue 4, July-August Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and by assessing the delivery of Metaclopramide for bypassing the hepatic first pass effect.
Formulation and evaluation of medicated chewing gum of Metaclopramide.
Urinary excretion profile showed that within the short span of time 1. The dose of chlorhexidine can be reduced significantly when used along with chitosan. Skip to main formulatioj Skip to main navigation menu Skip to site footer. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. The resulting chewing gum comprises a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work e. Motion Sickness Susceptibility, Autonomic Neuroscience: Guidelines Upcoming Special Issues.
Chewing gumChitosanChlorhexidineDental Caries. An attempt has cheewing made to formulate new chewing gum device for metaclopramide in the form of tablet.
The new drug delivery system was obtained, at room temperature conventional pharmaceutical equipment. The test group administered chewing gums containing chlorhexidine, with and without the polymer, while the control group administered dummy chewing gums.
Chlorohexidine Gluconate, Scholars Research Library, ; 2: Chewing gum, chitosan, chlorhexidine, dental caries. Different formulations of chewing gum with varying concentration of plasticizers like glycerol and castor oil were formulated. Naik H, Gupta S.
Publication Policies and Ethics. Drug release from a dosage form is the critical step in drug absorption and bioavailability, thus an experimental work has been designed to evaluate the efficiency of this kind of therapeutic system by verifying its capability to release the drug dose and cheiwng assessing the delivery of Dolasetron for bypassing the hepatic first pass effect.
Chitosan containing chewing gum has a greater antibacterial effect compared with gums containing only chlorhexidine.
FORMULATION AND EVALUATION OF MEDICATED CHEWING GUM OF DOLASETRON AS AN ANTIEMETIC AGENT
Madan N, Rathnam A. Chewing gums were prepared by using chlorhexidine and various proportions of gum base and chitosan.
The prepared gums were evaluated for physical parameters, compatibility studies, drug content, moisture content, stability studies and in vitro drug-release testing.
Paresh Mohan completed B. The resulting chewing gum tablets comprise a gum core combined with fillers, antioxidants, coloring agent and plasticizers, which provide smooth appearance and flexibility during storage and chewing. The aim of this study was to formulate chewing gum using chlorhexidine and chitosan and to prove its antibacterial and antiplaque properties effectively at low doses of chlorhexidine.
As the proportion of gum base was increased, an increase in hardness of the chewing gum was observed.
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Ann Jose ankara escort. The volunteers were visually examined for presence or absence of gingival erythema, gingival edema and gingival bleeding and the antibacterial activity was assessed by the reduction in evaluahion count in the plaque samples. Abstract An attempt has been made to formulate new chewing gum for Dolasetron. A Modern Era of Drug Delivery, international research journal of pharmacy, ; 2 Authors are permitted and encouraged to post their work online e.
The in vivo studies on human volunteers were carried out for optimized formulation F5 containing chitosan and antibacterial agent which showed a better reduction in the bacterial count and gingival index.